Gynostemma Pentaphyllum in Herbarium Blackwellianum (1757)

Gynostemma Pentaphyllum in Herbarium Blackwellianum (1757)

Jiaogulan (Gynostemma Pentaphyllum) is, like Ginseng, an adaptogen, which helps to normalize various processes in the organism.

Clinical trials have shown Jiaogulan is very effective in treating hypertension / elevated blood pressure 1.

In vitro laboratory tests have shown the ability of Jiaogulan’s contents to suppress the  propagation and growth  of cancer cells 2, 3, 4. In animal tests Jiaogulan has shown the ability to decrease and even stop the growth of malign tumors 5.


  • Triterpensaponines (82 Gypenosides) 6
  • Minerals 6
  • Vitamins 6
  • Amino Acids 6
  • Flavonoids 6
  • Polysaccharides 6
  • Antioxidants 6

Health Benefits and Therapeutic uses


Environmental and psychological stress can alter the balance between different organs and the stability of the whole organism (homeostasis) 6.  This can lead to many different diseases.

Adaptogens contribute to stabilize the homeostasis, and Jiaogulan and Gypenosides have shown in various human and animal studies to be extremely effective adaptogens 6, 7, 8.

Jiaogulan calms down nerves when overwrought, and stimulates them when more energy is needed 6,9,10,11. It also normalizes the function of the central nervous system (including the brain, the sympathicus and the parasympathicus) and of the hormone system 6,9,10,11.

Cancer treatment

The ginsenoside Rh2 is well known for its anti cancerogen properties 6. Jiaogulan contains the equivalent gypenosides 22-29, in considerably bigger amounts 6, 12, 13. They are proven to have cancer inhibitory effects on various types of cancer 6, 12, 13.

Application forms


Jiaogulan is usually consumed as a tea. Jiaogulan tea is made with boiling water, and left infusing for 8-10 minutes.

Fresh leaves

Jiaogulan can be grown relatively easy outdoors and even indoor, which can provide a steady supply of fresh Jiaogulan leaves.

Jiaogulan leaves can be consumed on top of breads, in fresh salads, in green smoothies, and of course they can also be used to make Jiaogulan tea.

Encapsulates Extracts

If a high dosage of specific ingredients is needed, encapsulated extracts are available, which can be ingested like any other nutritional supplement.

Scientific Sources

1 Lu, G.H., et al.  Comparative study on anti-hypersensitive effect of Gypenosides, Ginseng and Indapamide in patients with essential hypertension.  Guizuhou Medical Journal (in chinese). 1996
2 Jin, M., et al. Effect of Jiaogulan extract on a cell line from human rectal adenocarcinoma. Xian Dai Yin Yong Yao Xue (in chinese). 1992
Li, G.Y. Effect of gypenosides on synthesis of DNA and protein of liver carcinoma cells in vitro.  Xian Yi Ke Da Xue Xue Bao (in chinese). 1993
4 Li, H. Inhibitory effect of gypenosides on lung cancer cells in vitro.  Xi An Yi Ke Da Xue Xue Bao (in chinese). 1994
5 Wang, Chao-Jun, et al. A preliminary observation of preventive and blocking effect of Gynostemma pentaphyllum (Thunb.) Makino on esophageal cancer in rats. Huaxi Yixue Yuan Xuebao (Journal of West China University of Medical Sciences) (in chinese). 1995
6 Dr. Liu, Blumert. Jiaogulan – China’s ‘Immortality Herb’. Torchlight Publishing, 1999. ISBN 978-1-88708-916-6
7 Zhou, S.R. A preliminary study on the effects of Gynostemma pentaphyllum on endurance, spontaneous motor activity and superoxide dismutase in mice. Asia Pacific Journal of Pharmacology. 1990
8 Song, W.M., et al.  Comparison of the adaptogenic effect of Jiaogulan and Ginseng. Zhong Cao Yao (in chinese). 1992
9 Zhang, Yi-Qun, et al. Immediate effects of gypenosides-containing tonic on the echocardiography of healthy persons of various ages. Journal of Guiyang Medical College (in chinese). 1993
10 Zhou, Ying-Na, et al.  Influence of kiwifruit / jiaogulan recipe on the lung function and exercise endurance under exercise workload. Journal of Guiyang Medical College (in chinese). 1993
11 Liu, Jialiu, et al.  Overall health-strengthening effects of a gypenosides-containing tonic in middle-aged and aged persons. Journal of Guiyang Medical College (in chinese). 1993
12 Takemoto, T., et al.  Health before you know it. Amachazuru. Yutaka Nakano Shobo. 1984
13 Zhou, He-Ping. The saponin constituents and pharmacology of Gynostemma pentaphyllum Makino. Yaoxue Tongbao (in chinese). 1988

Additional Ressources